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Updated: Aug 6 2024

Infectious Diseases in Athletes

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https://upload.orthobullets.com/topic/3124/images/herpesgladiatorum.jpg
https://upload.orthobullets.com/topic/3124/images/tineacorporis.jpg
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  • Methicillin-Resistant Staph Aureus (MRSA)
    • MRSA is a bacterium which causes infection in humans
    • Epidemiology
      • community acquired MRSA increasing in sports
    • Pathophysiology
      • transmission is via direct contact with skin
      • exposed skin from abrasions ( "turf burns" ) significantly increases the risk of infection
      • sharing of razors, towels, soaps and personal hygiene products also increases risk
      • chances of prevention increased by
        • avoiding exposure of compromised skin
        • good hygiene
    • Presentation
      • manifests on the skin as a boil or pimple type lesion
      • can produce "spider-bite" type lesions
      • described as "pustules on an erythematous base"
    • Treatment
      • nonoperative
        • mupirocin
          • indications
            • initial treatment of small lesions
      • operative
        • irrigation & debridement with oral trimethoprim/sulfa and rifampin
          • indications
            • larger lesions
        • irrigation & debridement and IV antibiotics
          • indications
            • more severe infections
  • Herpes Gladiatorum
    • Herpes infections are a group of viral infections which manifest on the skin and/or in the nervous system
    • Epidemiology
      • common in wrestlers and rugby players
      • occurs in approximately 2% to 7% of wrestlers
    • Pathophysiology
      • caused by herpes simplex type 1 virus
      • transmitted via direct skin to skin contact
      • incubation 2-14 days
      • head, neck and shoulders primary areas of infection
      • if contacts the eye herpetic conjunctivitis can develop
    • Presentation
      • physical exam
        • clusters of fluid-filled blisters
        • rash
    • Treatment
      • nonoperative 
        • antivirals (acyclovir, valacyclovir, famciclovir)
          • indications
            • any active lesions
          • may return to play after
            • no new lesions have formed within the preceding 3 days
            • received at least 5 days of anti-viral medications
            • lesions have crusted over
  • Tinea Infections
    • A common fungal infection of the skin
      • include tinea pedis, corporis, capitis, and cruris (describes areas of body affected)
    • Epidemiology
      • common in wrestlers
    • Pathophysiology
      • tinea infections are caused by dermatophytes
      • transmitted by direct contact of fungus with skin
      • broken areas of skin can facilitate infection
    • Presentation
      • physical exam
        • scaly red patches in circular formation
        • example of tinea corporis (body) aka "ringworm"
    • Studies
      • diagnosis
        • scrapings from lesions are examined under microscope after preparation with potassium hydroxide
        • positive for tinea if hyphae are found
    • Treatment
      • nonoperative
        • topical antifungals
          • indications
            • tinea cruris, pedis and corporis
        • systemic antifungals
          • indications
            • tinea capitis
            • more severe cases of all forms tinea
        • no sports participation
          • indications
            • active infection
          • can return to play when
            • 72 hours of treatment
            • must be screened prior to competition
  • Acne Mechanica / Folliculitis
    • Skin condition that causes pimple like lesions
    • Epidemiology
      • occurs in athletes who are required to wear protective padding
        • hockey, football
    • Pathophysiology
      • primarily caused by mechanical friction and heat on exposed skin
      • occlusion of skin also a cause
    • Physical exam
      • red papules on skin
      • inflammation of follicles
    • Treatment
      • nonoperative
        • observation
          • indications
            • first line of treatment
            • most cases will resolve spontaneously after the season ends
        • keratinolytics such as tretinoin
          • indications
            • severe cases
      • prevention
        • wash immediately after play
        • athletic clothing that wicks away moisture
  • Impetigo
    • A highly contagious bacterial infection of the skin
    • Epidemiology
      • common in wrestlers
    • Pathophysiology
      • common pathogens include
        • streptococcus pyogenes
        • staphylococcus aureus
    • Presentation
      • initially present as fluid filled blister-like lesions
      • crusting noted after a few days
    • Treatment
      • erythromycin, topical bactroban
        • first line of treatment
      • no sports participation
        • indications
          • active infection
        • return to play
          • may return to play when all lesions are clear of crusting
  • Mononucleosis
    • A viral infectious condition characterized by fatigue and splenomegaly
    • Pathophysiology
      • caused by Epstein-Barr Virus (a herpes virus)
      • incubation period of 30-50 days
      • spread through saliva (kissing, sharing cups)
    • Presentation
      • symptoms
        • resolve in 4-8 weeks
        • 3-5 day prodromal period includes
          • malaise
          • myalgia
          • nausea
          • headache
        • Hoagland's triad
          • fever
          • pharyngitis (in 30%)
            • Group A streptococcus is responsible
            • exudative (white/grey pseudomembrane) in 50%
          • lymphadenopathy
            • posterior cervical chain
            • lasts 2-3 weeks
        • rash
          • common if treated with ampicillin/amoxicillin
          • petechial/maculopapular/urticarial
      • physical exam
        • splenomegaly
        • pharyngitis
    • Studies
      • heterophile Ab test (Mono-spot test)
        • 87% sensitive, 91% specific
      • viral capsid antigen (VCA) IgG and IgM
        • 97% sensitive, 94% specific
      • lab tests
        • absolute and relative lymphocytosis with >10% atypical lymphocytes
    • Imaging
      • generally unnecessary
      • ultrasound
        • if imaging is obtained, order ultrasound
        • noninvasive, reliable, has no radiation
      • CT
        • to exclude rupture
    • Treatment
      • nonoperative
        • fluids, hydration, acetaminophen, rest
          • isolation is unnecessary as transmissibility is low
        • no contact sports for 3-5 weeks
          • some take up to 3 months
          • indications
            • indicated in athletes until splenomegaly is completely resolved
            • most splenic rupture occurs in first 3 weeks
        • IM penicillin (one time) or PO penicillin (10 days)
          • erythromycin if allergic to PCN
          • indications
            • for strep pharyngitis
          • do NOT use amoxicillin
        • corticosteroids
          • decrease tonsillar size if there is difficulting swallowing/dehydration
        • advanced airway management
          • if there is respiratory distress
        • stool softener
          • decreases straining/Valsalva during bowel movements
    • Complications
      • splenic rupture
        • risk is 0.1-0.5%
        • most common in first 3 weeks
        • due to sudden increase in portal venous pressure
          • 50% atraumatic from Valsalva maneuver (rowing, weightlifting)
          • 50% from external trauma
      • aplastic anemia
      • Guillain-Barre syndrome
      • meningitis/encephalitis
      • neuritis
      • lymphoma
      • hemolytic uremic syndrome
      • disseminated intravascular coagulation
  • HIV and AIDS
    • AIDS is an immune deficiency condition caused by infection with the Human Immunodeficiency Virus (HIV)
    • Epidemiology
      • HIV can occur in any population
        • increased prevalence in hemophiliacs, IV drug abusers, and homosexual men
    • Pathophysiology
      • the CD4 cells (T-helper cells) are affected
    • Diagnosis
      • the diagnosis of AIDS requires an HIV positive test plus one of the following
        • CD4 count less than 200
        • diagnosis of an opportunistic infection
    • Treatment
      • no difference in treatment as compared to other athletes
        • use of universal precautions at all times
        • wound care
          • in the event of bleeding, compressive dressings should be used
          • participation in sport is restricted until all bleeding has ceased
        • participation in sports
          • HIV infection alone is insufficient grounds to prohibit an athlete from competition
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