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Review Question - QID 4668

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QID 4668 (Type "4668" in App Search)
A physician is interested in using platelet-rich plasma (PRP) for treatment of osteochondral lesions of the talus. He is reviewing a prospective cohort study that compares 40 patients treated with PRP and cast immobilization for 6 weeks vs. 36 patients treated conservatively with cast immobilization for 6 weeks. All patients were treated at the same time and institution. The study was not randomized although treatment and control groups were matched appropriately to reduce selection bias. Follow-up in each group was >80% over 1 year. The paper reported significant improvement with use of PRP based on three standard foot and ankle outcome scores (AOFAS, SF-36, FOAS). What is the level of evidence for this study?