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Review Question - QID 4751

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QID 4751 (Type "4751" in App Search)
A prospective randomized trial is conducted to test the efficacy of Vitamin C versus placebo in treating patients who develop complex regional pain syndrome (CRPS) after distal radius fractures. At first follow-up, the rates of CRPS are 1% and 9% in the study and placebo group, respectively. Which statistical test is most appropriate to determine significance?