summary Turner's Syndrome is a common congenital disorder caused by a missing X chromosome that presents with scoliosis, short stature, webbed neck, amenorrhea, cardiovascular abnormalities, and osteoporosis. Diagnosis is made with chromosomal testing showing a 45 XO genotype. Treatment involves a multidisciplinary approach to address orthopedic manifestations, cardiovascular abnormalities, and genitourinary anomalies. Epidemiology Incidence 1 in every 2,000 live births Demographics only in females less than 10% of cases are diagnosed antenatally largest proportion are diagnosed between ages 10 to 16 Etiology Genetics mutation 45 XO genotype Associated condtitions medical sexual infantilism malignant hyperthermia common with anethesia orthopaedic cubitus valgus idiopathic scoliosis (may be exacerbated by growth hormone therapy) genu valgum short 4th metacarpals congenital hip dislocation web neck osteoporosis Presentation Symptoms amenorrhea short stature webbed neck Physical exam amenorrhea with present uterus coarctation of the aorta may be evident on auscultation low hairline in back low-set ears extremity edema hypertension signs of thyroid dysfunction stool guaiac may identify GI bleeding Imaging Radiographs recommended views triplanar films of the hand biplanar knee films findings short fourth metacarpal on AP view genu valgum on AP of knees Treatment Nonoperative monitor for osteoporosis